Scale-up and Process Transfer of Freeze-Drying Recipes
نویسندگان
چکیده
منابع مشابه
Heat Transfer in Freeze-Drying Apparatus
Freeze-drying is a process used to remove water (or another solvent) from a frozen product, thus increasing its shelf-life. It is extensively used in pharmaceuticals manufacturing, to recover the active pharmaceutical ingredient (and the excipients) from an aqueous solution, as well as in some food processes, because of the low operating temperatures that allow preserving product quality. Moreo...
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1. Freezing: the product to be dried is put over shelves in a chamber and its temperature is lowered so that the water (or the other solvent) is frozen. Unfortunately, not all the solvent freezes forming ice crystals, but a certain amount (sometimes significant) remains bonded to the product and must be finally desorbed. In some cases the product (the drug and the excipients) does not crystalli...
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ژورنال
عنوان ژورنال: Drying Technology
سال: 2011
ISSN: 0737-3937,1532-2300
DOI: 10.1080/07373937.2011.597059